Problem
Drugs
There are many different types of drugs that have been reported to cause
problems in Collies, ranging from over-the-counter antidiarrheal agents
like ImodiumŪ to antiparasitic and chemotherapy agents. It is likely
this list will grow to include more drugs as our research progresses.
Drugs that have been documented, or are strongly suspected to cause
problems in dogs with the mdr1 mutation:
-
Ivermectin (antiparasitic agent)
-
Loperamide (ImodiumŪ; over-the-counter antidiarrheal agent)
-
Doxorubicin (anticancer agent)
-
Vincristine (anticancer agent)
-
Vinblastine (anticancer agent)
-
Cyclosporin (immunosuppressive agent)
-
Digoxin (heart drug)
-
Acepromazine (tranquilizer)
-
Butorphanol (pain control)
Potential Problem Drugs
The following drugs may potentially cause problems when given to dogs
that have the mutation. Biochemical studies have shown that this gene
has the potential to act on over 50 different drugs.
-
Ondansetron
-
Domperidone
-
Paclitaxel
-
Mitoxantrone
-
Etoposide
-
Rifampicin
-
Quinidine
-
Morphine
The most important and likely to be seen by the average owner are:
Ivermectin
Imodium
Acepromazine
Digoxin
Butorphanol
This list from Washington's Vet school web site on the mdr-1 gene
info. |
